A clash to conquer: the malaria parasite liver infection
نویسندگان
چکیده
منابع مشابه
Potent in vivo anti-malaria activity of Goniothalamin against rodent malaria parasite infection in mice
Goniothalamin was evaluated for its anti-malaria activity in-vivo, using the 4-Day Suppressive Test (Peters & Robinson, 1975). The test were carried out against two strains of rodent malaria parasites, the sensitive strain P. berghei ANKA (MRA 311) strain and the resistant strain P. yoelii (MRA 312). An Initial screening was carried out using a single dose of 10 mg/kg body weight administered s...
متن کاملPotent in vivo anti-malaria activity of Goniothalamin against rodent malaria parasite infection in mice
Goniothalamin was evaluated for its anti-malaria activity in-vivo, using the 4-Day Suppressive Test (Peters & Robinson, 1975). The test were carried out against two strains of rodent malaria parasites, the sensitive strain P. berghei ANKA (MRA 311) strain and the resistant strain P. yoelii (MRA 312). An Initial screening was carried out using a single dose of 10 mg/kg body weight administered s...
متن کاملHost ER stress during malaria parasite infection.
After transmission by Anopheles mosquitoes, malaria parasite sporozoites target the liver, where they infect hepatocytes and multiply thousands of times. The release of new parasites into the blood stream then initiates symptomatic red blood cell infection. Although successful replication within hepatocytes is critical for host infection, little is known about parasite–hepatocyte interactions t...
متن کاملHost Cell Phosphatidylcholine Is a Key Mediator of Malaria Parasite Survival during Liver Stage Infection
During invasion, Plasmodium, the causative agent of malaria, wraps itself in a parasitophorous vacuole membrane (PVM), which constitutes a critical interface between the parasite and its host cell. Within hepatocytes, each Plasmodium sporozoite generates thousands of new parasites, creating high demand for lipids to support this replication and enlarge the PVM. Here, a global analysis of the to...
متن کاملAntigen Export during Liver Infection of the Malaria Parasite Augments Protective Immunity
Protective immunity against preerythrocytic malaria parasite infection is difficult to achieve. Intracellular Plasmodium parasites likely minimize antigen presentation by surface-expressed major histocompatibility complex class I (MHC-I) molecules on infected cells, yet they actively remodel their host cells by export of parasite factors. Whether exported liver-stage proteins constitute better ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 2006
ISSN: 0950-382X,1365-2958
DOI: 10.1111/j.1365-2958.2006.05470.x